Best How To :

First of all, you need to implement a custom adapter for your ListView. Please, read this article if you are not familiar with this.

Next, you have to disable click on ListView items. If you don't know how, check this out.

Now, in your getView method from your custom adapter, you can find your Button and set up an onClickListener, but only after you have inflated the view for the current ListView position.

@Override
public View getView(int position, View convertView, ViewGroup parent) {
    LayoutInflater inflater = (LayoutInflater) context
        .getSystemService(Context.LAYOUT_INFLATER_SERVICE);
    View rowView = inflater.inflate(R.layout.rowlayout, parent, false);
    TextView textView = (TextView) rowView.findViewById(R.id.label);
    textView.setText(values[position]);

    Button mButton = (Button) view.findViewById(R.id.my_button_id);
    mButton.setOnClickListener(mClickListener);

    return rowView;
}